Senator Magalona was born in Saravia, Negros Occidental on November 5, 1891 to Vicente Magalona Y Ledesma and Agusttin Barrera y Majarocan.
He studied in Molo Institute, Iloilo where he obtained both his primary and secondary education. He graduated at San Juan de Letran with the degree of Bachelor of Arts in 1907 and La Jurisprudencia where he received his Bachelor of Laws degree in 1911.
He was elected Municipal President of Saravia in 1922 and re-elected to the same post in 1925. In 1926, he was elected President of the Municipal Presidents Convention at Bacolod, Negros Occidental. Senator Magalona was elected representative to the ninth and tenth Philippine Legislature from 1931 to 1934, and then, later elected assemblyman from the first district of Negros Occidental in 1935 and re-elected in 1938. He was elected Senator for two terms from 1946 to 1949 and from 1949 to 1955. Senator Magalona was chairman of the Committees on Accounts and Civil Service; Rules; Public Health; Labor and Immigration and National Exterprises. As lawmaker he authored, among others Republic Act. 342 (Moratorium Act); R.A. 611 (cumulative computation of vacation and sick leaves) and R.A. No. 709 (instruction of Spanish in colleges and universities).