Senator Francisco Enage was born in Tacloban, Leyte, on October 4, 1878 to Emeterio Enaje and Cleofe Abella.
Before he became a Lawyer, he was lieutenant in the Philippine Revolutionary Army and was wounded during an encounter with the American force in 1900.
He entered politics in the early part of American administration and was elected Municipal Councilor of Tacloban, Leyte. Later on he was elected provincial Governor of same province. He was Representative from the fourth district of Leyte from 1912 to 1916, and Senator ninth senatorial district comprising Leyte and Samar from 1919 to 1925. He was once a Floor Leader of the Philippine Assembly, and twice President Pro-Tempore of the Philippine Senate. He also held the position of Provincial Fiscal of Iloilo, Executive Secretary, and Judge of the Court of First Instance.
In the first Commonwealth elections held on September 17, 1935, he ran as an Anti candidate for Assemblyman from the fourth district of Leyte and won his seat; but, to avoid a deadlock in the election of Speaker of the National Assembly, for which office he was one of the candidates, he resigned as Assemblyman to accept the position of Technical Adviser in the office of the president at Malacañang.